Biogenesis of Nascent High Density Lipoprotein Particles
نویسندگان
چکیده
منابع مشابه
Characterization of nascent high density lipoprotein subfractions
Nascent high density lipoprotein (HDL) (1.063 < d < 1.21 g/ml) was isolated from recirculating rat liver perfusates and separated by heparin-Sepharose chromatography into a nonretained fraction (NR) and a fraction (R) that eluted with 0.5 M NaCI. Fractions NR and R contained 70% and 30% of the nascent HDL protein, respectively. ApoB-containing particles were removed from fraction R by chromatog...
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ABSTRACI Young chickens were administered L-[SH]leucine and after 10 or 30 min the livers were removed and fractionated into rough (RER) and smooth (SER) endoplasmic reticulum fractions and into light, intermediate, and heavy Golgi cell fractions. The labeled high density lipoprotein (HDL), contained within these intracellular organelles was isolated either by immunoprecipitation using rabbit a...
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Young chickens were administered L-[(3)H]leucine and after 10 or 30 min the livers were removed and fractioned into rough (RER) and smooth (SER) endoplasmic reticulum fractions and into light, intermediate, and heavy golgo cell fractions. The labeled high density lipoprotein (HDL), contained within these intracellular organelles was isolated either by immunoprecipitation using rabbit antiserum ...
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Plasma high-density lipoprotein cholesterol (HDL-C) concentration is a negative risk factor for atherosclerotic cardiovascular disease (CVD). Despite this, most attempts to raise plasma HDL-C concentrations in a cardioprotective way have failed. Recently, hypotheses about the atheroprotective effects of HDL have shifted away from quantity to quality, mostly HDL function in reverse cholesterol t...
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Motivated by experimental and numerical studies revealing that discoidal high-density lipoprotein (HDL) particles may adopt flat elliptical and nonplanar saddle-like configurations, it is hypothesized that these might represent stabilized configurations of initially unstable flat circular particles. A variational description is developed to explore the stability of a flat circular discoidal HDL...
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ژورنال
عنوان ژورنال: Structure
سال: 2015
ISSN: 0969-2126
DOI: 10.1016/j.str.2015.06.006